Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor
نویسندگان
چکیده
منابع مشابه
Structural landscape of the proline-rich domain of Sos1 nucleotide exchange factor.
Despite its key role in mediating a plethora of cellular signaling cascades pertinent to health and disease, little is known about the structural landscape of the proline-rich (PR) domain of Sos1 guanine nucleotide exchange factor. Herein, using a battery of biophysical tools, we provide evidence that the PR domain of Sos1 is structurally disordered and adopts an extended random coil-like confo...
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ژورنال
عنوان ژورنال: Biophysical Chemistry
سال: 2013
ISSN: 0301-4622
DOI: 10.1016/j.bpc.2013.02.008